Candidates who have passed Higher Secondary examination of the Board of Higher Secondary Education, Kerala, or examinations recognized equivalent thereto, with 50% marks in Biology separately, and 50% marks in Physics, Chemistry and Biology put together, are eligible. The candidates must score good ranks in KEAM entrance examinations of those years.

Biotechnology will not be considered as a subject for academic eligibility.

One out of 50 seat is reserved for the Lakshadweep candidate who is eligible for the seat.